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Although direct studies on volatile toxic metabolites in TCM and formulas remain limited, it has been successfully applied to assess changes in volatile components during processing and to detect contamination in TCM [65, 66]

Moreover, lipid peroxidation-driven plasma membrane rupture will accelerate KRAS-mediated pancreatic tumorigenesis by promoting DAMPs release, resulting in the activation of inflammatory pathways and polarization of macrophages for tumor growth [234]
Zinc deficiency correlates with severity of diabetic polyneuropathy
