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In this model, LN metastasis serves as an important prognostic factor and triggers lymphadenectomy to prevent tumor cells from spreading further to distant organs (150152)

During the reproductive period, estrogens secreted by the ovaries have a protective effect on lipid metabolism and the functions of the vascular endothelium

10.1186/s12929-017-0385-1 63 SakuraiT.HeG.MatsuzawaA.YuG.-Y.MaedaS.HardimanG.et al (2008)

Iyer & Tanenberg, 2013)

1e,f, Extended Data Fig