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The peptide binds copper(II) with high affinity (log K = 16.44 at physiological pH), and this copper binding is essential for many of its biological activities

TrustScore 5.00 Make supplements work for you Get the app to see TrustScore details Nutrients Suggested use: Take 10 pumps (2mL) daily by mouth or in a glass of water

Cell were then treated with Cy5.5-labeled NP4 for 1 h, 4 h, or 7 h, respectively, washed with PBS, and analyzed by flow cytometry (Beckman Coulter, U.S.A.)

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In contrast, AMYRs have high affinity and potency in response to amylin peptides, but weak response to human CT (hCT) 7,8