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But under oxidative stress conditions induced by reactive species, toxins or ARE inducers, the association between Nrf2 and Keap1 is disrupted and Nrf2 translocates to the nucleus of the cell, where it binds to small Maf proteins that increase the transcription of genes driven by ARE [67]

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doi:10.1002/mds.870130205 pmid:9539333 Baroja-Mazo A, Barber-Cremade M, Pelegrn P (2013) The participation of plasma membrane hemichannels to purinergic signaling