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10.1039/d3ra05840a 55

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However, as the placebo effect was significant, a positive proof of concept with respect to adalimumab could not be demonstrated

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The researchers reported modulation of immune-related gene expression, though the clinical significance of these findings remains to be established

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But they are changing the landscape of medicine because they hit a fundamental biology we have ignored for too long: the gut-brain-metabolic axis

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