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Based on the results patients with Xx, Aa, and RR genotype predominance are more prone to melasma ( 3 Melasma pathophysiology As mentioned previously, the development of melasma can be affected and precipitated through the various factors including long-term sun-exposure and UV radiation, genetic predisposition, thyroid dysfunction, special drugs, oxidative stress, hormonal imbalance, and female gender especially the pregnant women and also those who are consuming oral contraceptives (OCPs) (Ortonne et al., 2009

Effects of dietary lipid levels on growth, lipid metabolism, fatty acid composition and antioxidant capacity of juvenile greasyback shrimp (Metapenaeus ensis) Aquacult Rep

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Again they found increased expression of ABC transporter genes, and increased susceptibility to ivermectin after the addition of cyclosporin A (Pohl et al