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Clinically meaningful body weight reductions were observed, with petrelintide achieving up to -8.6% weight loss compared to -1.7% with placebo after 16 weeks

The parallel decline in endogenous GHK-Cu levels is suggestive, though causation has not been established

However, when there is an excess amount of cytosolic DA outside of the synaptic vesicle in damaged neurons, i.e., after L-DOPA treatment, DA is easily metabolized via monoamine oxidase (MAO) or by auto-oxidation to cytotoxic ROS (Zucca et al., 2014)