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Chronic inflammation is a crucial hallmark of persistent infection (193), as infections can alter proinflammatory and anti-inflammatory cytokine and chemokine expression, adjusting the inflammatory and immune responses (30)

Decreased peripheral target tissue responsiveness to insulin action leads to insulin resistance (IR), a complex pathophysiological condition with reduced sensitivity, impaired ability to inhibit glucose production and stimulate peripheral glucose elimination, and often accompanied with hyperinsulinemia to maintain blood sugar stability (1)

Cellular and molecular biology of aging endothelial cells

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