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For some systems, this sudden shift in gut signaling could be interpreted by the brain's chemoreceptor trigger zone (the area that controls nausea and vomiting) as a sign of trouble, leading to a nauseous sensation
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Notably, a study involving approximately 276,000 participants from the UK Biobank cohort revealed that permanent night shift work, a condition acknowledged to reduce 24-hour melatonin levels [41], was associated with a 1.5-fold higher risk of developing AD during a median follow-up of 9 years [42]
