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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
Replacement of Tyr by Phe reduces the catalytic activity [207]
Penn responded on his website
In liver ischemiareperfusion injury, propofol (1 mgkg 1 ) effectively inhibited mitochondrial oxidative stress, reducing liver damage by mitigating hypoxia-inducible factor 1 alpha (HIF-1)-driven mitochondrial dysfunctions and cell apoptosis [22]
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