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The p53 protein has various functions in regulating cellular homeostasis, one of which includes transcriptional antagonism of NF-B, a key positive regulator of inflammation [220, 221]

It may seem obvious that we want the clock to tell us something about biological aging at the root level

Galanski, M

The metalloprotease ADAMTS8 displays antitumor properties through antagonizing EGFR-MEK-ERK signaling and is silenced in carcinomas by CpG methylation