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It not only activates Nrf2 to inhibit hepatic steatosis, but also induces the apoptosis and autophagy of hepatoma cells to exert an anti-hepatoma effect (Lu et al., 2017)

These data demonstrated that GPX3 antagonized autophagy and the associated ferroptosis by inhibiting AMPK/mTOR

Francque S, Verrijken A, Caron S, Prawitt J, Paumelle R, Derudas B, Lefebvre P, Taskinen MR, Van Hul W, Mertens I, Hubens G, Van Marck E, Michielsen P, Van Gaal L, Staels B (2015) PPARalpha gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis

[DOI] [PubMed] [Google Scholar] 111.de S V
