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The druglike and orally bioavailable compounds identified herein are active in animal models of schistosomiasis with a broader range of developmental stages targeted than the drug of choice, PZQ

Loop 3 provides the necessary flexibility in the ABS of the bacterial GUSs to accommodate various substrates According to the enzyme-activity analysis, all GUSs accepted one or more substrates larger than 10 , but the superimpositions of Cp GUS and Rg GUS with the Bifd GUS E479A / 10 complex indicated possible steric clashes between the aglycone and loop 5 or loop 3 of Cp GUS and Rg GUS, respectively

Non-enzymatic antioxidants include ascorbate, glutathione, carotenoids, tocopherols, alkaloids, and phenolic compounds such as flavonoids and tannins

TGF- has been shown to downregulate activity of Glutamine Cysteine ligase, a rate-limiting step enzyme involved in the synthesis of GSH [75]

While not in this study, liposomal GSH has also been found to improve glutathione levels