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The giant astrocytes still induce differentiation of OPCs into fully myelinating oligodendrocytes to compensate for demyelination, but these cells arent fully capable of migrating into lesion areas

These same studies also found improvements in mitochondrial function, metabolic markers, and reductions in oxidative stress and inflammation

SMAD4 gene mutation predicts poor prognosis in patients undergoing resection for colorectal liver metastases

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The HLA-Cw6 allele, in particular, enhances the presentation of auto-antigens to CD8 + cytotoxic T lymphocytes, promoting a cytotoxic response against keratinocytes