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Unfortunately, hardly any genetic markers have so far been identified as predictors of efficacy or ADRs that could be useful for the development of dosing guidelines [30]

In contrast to ovulation-inducing drugs like letrozole and clomiphene, ellagic acid restores follicular dynamics via reducing oxidative stress and restoring normal ovarian morphology, rather than directly altering estrogen receptors

Mechanistically, hemin leads to inhibition of the Kelch-like ECH-associated protein 1 (Keap1)-dependent ubiquitination and degradation of Nrf2

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Cell Rep (2019) 27(7):20632074e5