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In MI, the activation of Wnt/-catenin signaling promotes NF-B nuclear translocation through TrCP-mediated degradation of phosphorylated IB

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While the Fe-S cluster is critical for activity, its role for the reaction mechanism remains unclear ( in vitro using glutathione disulfide (GSSG) or in vivo in response to ozone and paraquat, and inactivated upon reduction (Kopriva and Koprivova, 2004)