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10.1093/femspd/ftv040 Pathog

One thing is certain: As we age, less glutathione is produced

doi: 10.3389/fnut.2025.1587246 Received 07 March 2025 Revised 16 November 2025 Accepted 28 November 2025 Published 17 December 2025 Volume 12 - 2025 Edited by Ingrid Lofgren, University of Rhode Island, United States Reviewed by Sergio A

143 (Pt 3), 113617

Introduction Although nitric oxide (NO) has been posited as a deleterious molecule from a physiological perspective ( In the context of exercise, nitrate supplementation has gained interest as an ergogenic aid to enhance endurance performance ( Therefore, the purpose of this review is to present the general knowledge of the underlying physiological mechanisms affected by NO and the subsequent effect of nitrate supplementation in exercise