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Metabolic analysis of patient-derived NSCs showed reduced levels of non-mitochondrial oxygen consumption, increased basal respiration and ATP production

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Of two natural variations identified in the nucleotide binding motif (GTEILGKS) in the intracellular loop between the fourth and fifth transmembrane domains (T219K and S225L) only one (S225L) impairs significantly carnitine transport activity ([91] and unpublished results)

Apesar de estudos de longa durao terem verificado alteraes enzimticas sugestivas, os nicos casos onde se comprovou a melhoria na performance de atividades fsicas foram em condies patolgicas, como doenas renais (AHMAD et al, 1991), vasculares (BREVETTI et al, 1988) e sndrome de fadiga crnica

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