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If preclinical toxicology suggests that a drug candidate has effects on cardiac conduction or effects on human etheragogo channels, continuous ECG monitoring and triplicate ECGs obtained in conjunction with plasma sampling for PK evaluation would be useful once the dose or range of doses to take forward into further development is determined

The powder should dissolve within 13 minutes

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Upon IN administration, the polymer moieties get arranged into micellar packing and form a viscous gel at the body temperature

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