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The copper concentration used in experiments critically influences cellular responses: low levels (0.10.1.2mmol/l) induce physiological/adaptive transcriptional changes, while higher levels (0.4-0.4.6mmol/l) trigger toxic, stress-related responses [24]

Animal studies show that direct BDNF infusion into the hippocampus produces antidepressant effects, while blocking BDNF signaling prevents antidepressants from working

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