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Description
Initially, the majority of clinical investigations into KOR antagonists have focused on populations with mood or substance-use disorders, rather than schizophrenia

GABA production by human intestinal bacteroides spp.: prevalence, regulation, and role in acid stress tolerance

Bannister AJ, Kouzarides T

J., Prihoda, T
The strongest human evidence is topical, including the Leyden 2002 photoaging trial and a 2023 IRB-approved 21-woman topical NEEL gel study reporting an average 28% increase in skin collagen density at 3 months
