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At high pharmacological doses, such as 20 mg, melatonin operates fundamentally differently than it does at physiological sleep-inducing doses

As telomeres are triple-guanine-containing sequences that are highly susceptible to damage by oxidative stress, the authors suggested that alcohol metabolism-related ROS generated by CYP2E1 could reduce telomere length by inducing double-strand breaks and interfering with the DNA replication fork [129] and telomere shortening may be accelerated by thiamine deficiency [58]

10.1111/bdi.12416 503 ZangY.LaiX.LiC.DingD.WangY.ZhuY

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