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Description
Under homeostatic conditions, Nrf2 is retained in the cytoplasm through interaction with Keap1, which targets it for ubiquitin-mediated proteasomal degradation
At the time of these studies, the roles of reactive oxygen species (ROS) in cells were poorly characterised and information on subcellular compartmentation was at best fragmentary
These are not safety findings they are gaps in the safety dataset
Protein Glutathionylation in Health and Disease
Yap5 is an iron-responsive transcriptional activator that regulates vacuolar iron storage in yeast
