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Prunes preserve hip bone mineral density in a 12-month randomized controlled trial in postmenopausal women: the Prune Study

(2001, Int J Obes) showed that chronic treatment with AOD-9604 restored repressed beta-3 AR mRNA levels in obese mice toward lean-mouse values, characterizing a chronic-treatment mechanism that complements the fragment's acute lipolytic action

For anything causing significant discomfort, functional impairment, or progressive worsening, adjustment or discontinuation is prudent

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