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doi:10.3389/fnins.2022.874750

The intricate study on the mechanism of action of Rg1 reveals valuable therapeutic possibilities, yet constituting obstacles for researchers trying to design success studies

Key gaps include limited direct cytotoxicity data for the 1723 fragment across diverse cell types, limited blood-compatibility data, limited formal immunogenicity data for the fragment, limited toxicokinetic information, limited local-tolerance information, limited reproductive and developmental toxicology data, limited genotoxicity data, and the absence of broadly applicable GLP-compliant repeat-dose toxicology packages for marketplace research materials

The blurring has abated to some some degree
