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doi: 10.1186/s12989-024-00599-1

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Some transcription factors regulate ferroptosis-related genes in response to oxidative stress, for example, p53 decreases cystine uptake by inhibiting the expression of Solute carrier family 7 member 11 (SLC7A11), one of the components of the Xc system, thereby increasing cellular susceptibility to ferroptosis [122]

Figure 3 While IPA incorporates p -values, z -scores, and other analyses to address statistical biases based on population subsets ( z -score ranges that were substantially lower than those calculated for the actual sample datasets (average random z -score range = ~ 2.5