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Krppel-like factors (KLFs) are major players in transcriptional networks that control proliferation, apoptosis, differentiation, development, and tumorigenesis

doi: 10.1016/j.cyto.2009.08.010 166 LiS.ZhaoF.YeJ.LiK.WangQ.DuZ.et al

Morescalchi F, Duse S, Gambicorti E et al (2013) Proliferative vitreoretinopathy after eye injuries: an overexpression of growth factors and cytokines leading to a retinal keloid
Although preclinical studies suggest antitumor activity via modulation of the cell cycle, apoptosis, and angiogenesis, large-scale randomized controlled trials have not demonstrated a clear benefit in terms of cancer incidence or mortality (11)

Beyond symptom management, IV therapy supports immune health and nutrition, which are often compromised in rheumatic conditions
