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The ability of Fn to invade epithelial cells via FadA binding to CDH1 (E- cadherin) and to promote inflammation and oncogenic signalling has been demonstrated using HCT116 xenograft mice (73) and Fn infection in an Apc Min/+ mouse model lead to the generation of a proinflammatory microenvironment (59)

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Interleukin inhibitors Ustekinumab is an antagonist of the p40 subunit of pro-inflammatory cytokines interleukin-12 and interleukin-23, recently licensed for induction and maintenance therapy in CD and UC[9597]

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