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It is well documented that there is a relationship between gallstones, diabetes and the metabolic syndrome

The same may be performed later in life as late-onset symptoms appear

In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The metabolic and molecular basis of inherited disease, 8th edn

Al-Biltagi M, Isa M, Bediwy AS, Helaly N, El Lebedy DD

And once HDL becomes mature, it may transfer cholesterol and phospholipid, through the action of cholesteryl ester transfer protein (CETP) and phospholipid transfer protein (PLTP) to apo B-containing lipoproteins, in exchange for triglyceride which is then hydrolyzed by the action of hepatic lipase [27]