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Research has shown that GLP-1s effectively reduce blood glucose in people with type 2 diabetes

Another explanation for metformins wide-ranging benefits has more recently gained recognition: its ability to impact the gut and the intestinal microbial community (microbiome) (McCreight 2016

LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: from discovery to clinical proof of concept

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Additionally, environmental stressors like heavy metals and pesticides have been shown in experimental models to impair proteasome function, promote syn aggregation, and drive dopaminergic neuron loss, underscoring the multifaceted contribution of UPS impairment to PD pathogenesis [170]