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Description
CEBPB orchestrates immunosuppressive gene activation (Arg-1, COX2, NOS2, NOX2) by partnering with Lnc-17Rik to remodel the transcriptional repressor complex (LAP/LIP/CHOP), recruiting WDR5 for H3K4me3 enrichment at target promoters, thereby amplifying myeloid-derived suppressor cell function and tumor progression, with its human homolog exhibiting marked overexpression in myeloid-derived suppressor cells (MDSCs) from esophageal cancer patients [28]
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[DOI] [PubMed] [Google Scholar] 13.Dunning KR, Russell DL, Robker RL
