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It is necessary to establish multi-center, cross-platform data integration systems to strengthen the connection between basic research and clinical data, improving drug prediction accuracy and therapeutic consistency [188]

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Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo : insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression

Begin with every other day (or only 2-3x per week) and work up to daily applications
