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Therefore, its role in regulating carnitine traffic is plausible [87]

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Berberine side effects are predominantly gastrointestinal and may include: Diarrhoea, constipation, or abdominal discomfort Nausea and flatulence Cramping or bloating These effects are typically dose-dependent and may be minimised by starting with lower doses and taking berberine with meals

Since these metabolic reactions occur mainly in the liver, impairment in this pathway could lead to the accumulation of excess metabolites, including byproducts of amino acid and lipid metabolism, in the liver and thereby contribute to the pathogenesis of Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) 12,13