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Serious reactions are rare, especially when treatment is clinically appropriate
If a research vial is still clear at day 20, you are making an educated judgment based on general protein behavior

Strengthens the Immune System B-12 plays a role in building resilience against illness
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One would surely argue that some groups are more at risk for B12 deficiencies and could, therefore, benefit from injections: vegetarians and vegans have impaired B12 absorption due to changes from diet, while older adults have changes due to aging
