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10.1016/S0165-6147(00)01609-6 47 WagenerF

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The activity of SIRT1 also modulates the formation of H3K9me3, H4K20me3 and H3K79me2 to regulate chromatin

A five-year clinical trial in which 619 hemodialysis patients who received 2.5 mg of folic acid, 1 mg of vitamin B12, and 50 mg of vitamin B6 daily had significantly lower plasma levels of homocysteine

However, realizing these therapeutic outcomes will require further advances in drug design, comprehensive clinical studies, and an enhanced understanding of the molecular mechanisms underlying their pharmacological effects