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including 768 healthy controls, 133 patients with mild cognitive impairment, and 211 Alzheimer disease patients) found a U-shaped relation between RBC folate and plasma tHcy, such that higher tHcy was observed with the lowest and highest RBC folate concentrations compared with intermediate concentrations

When to Seek Medical Advice About B12 and Sleep Issues Whilst vitamin B12 supplementation rarely causes sleep disturbances, certain situations warrant medical evaluation