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1 Introduction Autism spectrum disorder (ASD) is a lifelong neurodevelopmental disorder characterized by deficits in social communication and interaction, as well as restricted and repetitive patterns of behavior, interests, and activities, often accompanied by atypical sensory-motor responses (Lord et al., 2018)

As it is known that transactivation of Met can occur via epidermal growth factor (EGF)-dependent EGF receptor (EGFR) activation or through a constitutively activated EGFR pathway 20 , we examined whether inhibition of EGF-induced phosphorylation of EGFR by the dimeric macrocycles caused the bell-shaped response mentioned above

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