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Additionally, it raises calcium levels in the brain, which can cause abnormal tau phosphorylation and neuronal death (Kamat et al., 2013)
For broader context on aging biology and metabolic decline research, the NIH National Institute on Aging provides authoritative resources on the metabolic changes and epigenetic mechanisms that underlie age-associated obesity and sarcopenia
The accumulation of iron may cause a rise in the intracellular labile iron (II) pool and Fenton reaction, which results in the production of lipid ROS, and ferroptosis
