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I spent a few weeks reading clinical studies before deciding to try it

The reasonable scientific conclusion is that CagriSema is a promising but unproven candidate for obesity-related liver disease: mechanistically coherent, backed by strong component-level (semaglutide) human data and preclinical amylin signals, yet lacking any direct combination trial in liver disease

doi: 10.1289/ehp.1003170

Similarly, associations among serum IGF-1 concentration and serum levels of phosphate, calcium, FGF23 and bone mineral density have been shown in patients with advanced CKD, which also supports the link between mineral metabolism and IGF-1 regulation in CKD patients.73 In patients with acromegaly, higher renal IGF-1 is associated expression with increased serum and urinary calcium levels, elevated serum phosphate and calcitriol concentrations, along with decreased serum PTH levels
