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In the SURMOUNT-5 head-to-head comparison with semaglutide, tirzepatide produced approximately 20% greater body weight reduction, establishing it as the more potent weight loss agent currently available.[5] PCOS-specific RCT data for tirzepatide is less mature than for semaglutide no large completed trials in PCOS populations exist as of early 2026 but the mechanistic case is compelling

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Interestingly, VCAM-1a protein expressed by endothelial cells in the BBB that is involved in peripheral immune cell recruitmentexpression increases in the aged brain, and the application of anti-VCAM-1 antibodies reduces microglial reactivity and improves memory and learning in aged (19-month-old) mice (Yousef et al., 2019)

Cell Mol Immunol 12:523

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