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They work by: Slowing gastric emptying , which prolongs feelings of fullness Reducing appetite through effects on brain centres that regulate hunger Improving insulin secretion and glucose metabolism Potentially reducing food intake and affecting eating behaviours These injections are administered subcutaneously, typically once weekly (semaglutide) or once daily (liraglutide), and have been approved by the MHRA for weight management in adults with a BMI 30 kg/m, or 27 kg/m with weight-related comorbidities, as an adjunct to reduced-calorie diet and increased physical activity

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In addition to its use in ulcerative colitis clinical trials[2-7] and its effectiveness in various models of colitis[30-35], BPC 157 reduces high myeloperoxidase (MPO) activity in colonic tissue[33], heals fistulas[36-38], rescues failed anastomosis healing[30,34,39,40] and markedly improves intestinal adaptation following massive bowel resection[40]