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Redox Biol 62:102708
The leucine antagonist N -acetyl-leucine amide (NALA) inhibits mTORC1 activity and T cells function, impairs IL-2 and IFN production in in vitro Th1 polarized murine T cells ( via the small G proteins RagA/B and Rheb1/2 to drive their suppressive activity by inducing the expression of inducible T cell costimulator (ICOS) and CTLA4
A computational protocol was developed to identify appropriate sites in the nanobody for incorporating p-acetylphenylalanine (pAcF)
doi: 10.1172/jci.insight.145207 146 OlivaCRNozellSEDiersAMcClugageSG3rdSarkariaJNMarkertJMet al
