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In this respect, preclinical studies demonstrated that 3-AR agonism may counteract the effects of hyperoxia in the ileum of newborn rats thus extrapolating its use to neutralize the damaging effects of sudden exposure to hyperoxia induced by preterm birth (Nardini et al., 2024, 2025)
These ROS contribute to lipid peroxidation, damage to cellular components, and the inactivation of antioxidant enzymes like superoxide dismutase (SOD) and catalase, leading to RPE dysfunction [39,40]

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