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Preclinical: In one study, mice were administered 2.5 g IN-NGF (75 g/kg) and rats 10 g IN-NGF (50 g/kg) in staggered doses, 60 min prior to behavioral assessment and post-mortem biochemical analysis

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Nebraska : Omaha

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In the absence of reduced cysteine, the addition of an acetyl group to cysteine (N-acetyl-cysteine [NAC]) provides the ability for a molecule to cross the cell membrane and promotes intracellular glutathione synthesis.[117] It is synthesized in cytosol outside the ribosomes that requires ATP, but does not require the participation of RNA

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10.1136/bmjopen-2018-022188 BMJ Open

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Itaconate and fumarate derivatives inhibit priming and activation of the canonical NLRP3 inflammasome in macrophages

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