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Through integrated transcriptomic and metabolic analyses, we found that NOTCH1 -mutated cells exhibit a distinct bioenergetic profile, characterized by upregulation of mitochondrial programs, enhanced oxidative phosphorylation, and elevated ROS production, all hallmarks of an active mitochondrial phenotype (Figs

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This paper extends prior efforts to clarify the mechanisms underlying the protective effect of dietary energy restriction on neoplastic growth, documenting changes in gene expression within tumours as a function of host diet

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