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This is believed to be linked to the potent antioxidant abilities of L-Glutathione, as free radicals contribute to age-related changes and the deterioration of brain health
Dong Q, et al
Similarly, miR-124 sensitizes CD133 (+) HCC cells to cisplatin-induced apoptosis by promoting ROS generation and c-Jun N-terminal kinase (JNK) phosphorylation, highlighting the potential of targeting the miR-124/SIRT1/ROS/JNK pathway to overcome drug resistance (Xu et al., 2019)
This does not mean topical GSH is useless
Li et al., 2009), glutathione may influence JA signaling through several GSTs and GRX
