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Description
Liver and pancreatic tissues samples were carefully excised, snap frozen and stored at 80 0 C for further experimentations (Figure 1)

Benfotiamine, a lipid-soluble thiamine derivative, is thought to inhibit three major diabetes-related pathways (hexosamine, AGE formation, and DAG-PKC pathways), which alter gene expression and protein function, causing vascular dysfunction, inflammation, and oxidative stress, all of which contribute to the pathogenesis of DPN

J Card Surg
Peroxide Metabolism in the Erythrocyte It is the lack of NADPH that causes hemolysis of erythrocytes, because H 2 O 2 and other reactive oxygen species cannot be reduced, leading to oxidation of hemoglobin to methemoglobin and membrane damage (Ruwende and Hill 1998)

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