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To examine the effects of oxidation during processing, in vitro ligand fishing experiments were performed where metabolites were initially extracted in solvent and then passed over the immobilized GST, thereby reducing the potential for spontaneous, or enzyme-catalyzed oxidative reactions

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Systemic inflammatory profile and response to anti-tumor necrosis factor therapy in chronic obstructive pulmonary disease

KD decreases the expression of pro-inflammatory proteins, such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase, which modulate the activity of cytokines IL-1, IL-2, IL-4, IL-6 and TNF- [38, 56]

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