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Transiently, ECF osmolarity is higher than ICF osmolarity, which causes water to shift from ICF to ECF, decreasing ICF volume and increasing ECF volume

[10] Long-term use of proton pump inhibitors (PPIs) and H2-receptor antagonists reduces gastric acid, potentially impairing the release of B12 from dietary proteins

the copper chelate degrades faster and more visibly

Therefore, an intramuscular injection of hydroxocobalamin produces higher serum level than the same dose of cyanocobalamin