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Limitations such as a possible ceiling effect in patients receiving effective bosentan therapy could be responsible for the insignificant difference between the groups
K.MurzilliS.PoggiA.et al (2009)
Kullisaar et al
Additionally, several rare pathogenic variants in SCN9A have been identified in patients carrying small fiber neuropathy [92], further underscoring the critical involvement of this gene in potentiating the mechanism of neuropathic pain
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